Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4606506..4607044 Replicon chromosome
Accession NZ_CP085813
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Minun

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag LJF39_RS22410 Protein ID WP_001526148.1
Coordinates 4606769..4607044 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag LJF39_RS22405 Protein ID WP_000729713.1
Coordinates 4606506..4606766 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF39_RS22390 (4602259) 4602259..4603812 + 1554 WP_000013013.1 TROVE domain-containing protein -
LJF39_RS22395 (4604160) 4604160..4605374 + 1215 WP_001105533.1 RNA-splicing ligase RtcB -
LJF39_RS22400 (4605378) 4605378..4606397 + 1020 WP_000101024.1 RNA 3'-terminal phosphate cyclase -
LJF39_RS22405 (4606506) 4606506..4606766 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF39_RS22410 (4606769) 4606769..4607044 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
LJF39_RS22415 (4607132) 4607132..4609837 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T221826 WP_001526148.1 NZ_CP085813:4606769-4607044 [Salmonella enterica subsp. enterica serovar Enteritidis]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T221826 NZ_CP117600:c2906705-2906553 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATCTGAAAGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT221826 WP_000729713.1 NZ_CP085813:4606506-4606766 [Salmonella enterica subsp. enterica serovar Enteritidis]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT221826 NZ_CP117600:2906762-2906810 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References