Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4056477..4057079 Replicon chromosome
Accession NZ_CP085813
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Minun

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag LJF39_RS19860 Protein ID WP_001159635.1
Coordinates 4056768..4057079 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF39_RS19855 Protein ID WP_000362050.1
Coordinates 4056477..4056767 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF39_RS19840 (4053970) 4053970..4054872 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LJF39_RS19845 (4054869) 4054869..4055504 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF39_RS19850 (4055501) 4055501..4056430 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF39_RS19855 (4056477) 4056477..4056767 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF39_RS19860 (4056768) 4056768..4057079 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF39_RS19865 (4057297) 4057297..4058226 + 930 WP_001127705.1 alpha/beta hydrolase -
LJF39_RS19870 (4058312) 4058312..4058623 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
LJF39_RS19875 (4058620) 4058620..4059066 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF39_RS19880 (4059081) 4059081..4060022 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF39_RS19885 (4060067) 4060067..4060504 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF39_RS19890 (4060501) 4060501..4061373 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF39_RS19895 (4061367) 4061367..4061966 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T221822 WP_001159635.1 NZ_CP085813:c4057079-4056768 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221822 NZ_CP117600:c2022085-2021951 [Escherichia albertii]
ATGCTGACAAAAATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTCGCTGTGTGAGTTGAGTAT
CAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221822 WP_000362050.1 NZ_CP085813:c4056767-4056477 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221822 NZ_CP117600:2022130-2022177 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References