Detailed information of TA system TA221805

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2011756..2011981
• Replicon: chromosome
• Accession: NZ_CP085813
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Minun

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF39_RS09925
• Protein ID: WP_000813254.1
• Coordinates: 2011756..2011911 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2011923..2011981 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF39_RS09890	2006863..2007144	-	282	WP_000445513.1	phage holin family protein	-
LJF39_RS09895	2007134..2007322	-	189	WP_001688615.1	putative holin	-
LJF39_RS09900	2007316..2007639	-	324	Protein_1933	tellurite/colicin resistance protein	-
LJF39_RS09905	2009810..2010346	-	537	WP_000640113.1	DUF1133 family protein	-
LJF39_RS09910	2010343..2010633	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF39_RS09915	2010633..2011232	-	600	WP_000940751.1	DUF1367 family protein	-
LJF39_RS09920	2011295..2011465	-	171	WP_000734094.1	hypothetical protein	-
LJF39_RS09925	2011756..2011911	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2011923..2011981	+	59	-	-	Antitoxin
LJF39_RS09930	2012338..2013270	+	933	WP_000556390.1	hypothetical protein	-
LJF39_RS09935	2013267..2013821	+	555	WP_001033796.1	hypothetical protein	-
LJF39_RS09940	2013983..2014312	-	330	WP_001676916.1	DUF977 family protein	-
LJF39_RS23020	2014356..2014403	-	48	Protein_1942	hypothetical protein	-
LJF39_RS09950	2014585..2015052	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF39_RS09955	2015437..2015592	+	156	WP_085981757.1	DUF1391 family protein	-
LJF39_RS09960	2015700..2016221	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF39_RS09965	2016659..2016880	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2006321..2016221	9900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221805 WP_000813254.1 NZ_CP085813:c2011911-2011756 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221805 NZ_CP117595:2075085-2075188 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 59 bp

>AT221805 NZ_CP085813:2011923-2011981 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin