Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | unclassified/- |
Location | 2988554..2989202 | Replicon | chromosome |
Accession | NC_009525 | ||
Organism | Mycobacterium tuberculosis H37Ra |
Toxin (Protein)
Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
Locus tag | MRA_RS14155 | Protein ID | WP_003899414.1 |
Coordinates | 2988554..2988877 (-) | Length | 108 a.a. |
Antitoxin (Protein)
Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
Locus tag | MRA_RS14160 | Protein ID | WP_003899415.1 |
Coordinates | 2988957..2989202 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MRA_RS14135 | 2984128..2985389 | + | 1262 | WP_143711313.1 | IS3-like element IS987 family transposase | - |
MRA_RS22775 | 2985416..2985601 | - | 186 | WP_009935348.1 | hypothetical protein | - |
MRA_RS14140 | 2985763..2987202 | - | 1440 | WP_009935349.1 | phage major capsid protein | - |
MRA_RS14145 | 2987210..2987743 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
MRA_RS21765 | 2987896..2988387 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
MRA_RS14155 | 2988554..2988877 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
MRA_RS14160 | 2988957..2989202 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
MRA_RS14165 | 2989199..2990626 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
MRA_RS14170 | 2990628..2991020 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
MRA_RS14175 | 2991017..2991277 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
MRA_RS14180 | 2991294..2991656 | - | 363 | WP_003900543.1 | hypothetical protein | - |
MRA_RS14185 | 2991659..2992786 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
MRA_RS14190 | 2992931..2993158 | - | 228 | WP_003899421.1 | hypothetical protein | - |
MRA_RS21770 | 2993155..2993544 | - | 390 | WP_003899422.1 | hypothetical protein | - |
MRA_RS14195 | 2993450..2993722 | + | 273 | WP_003900544.1 | hypothetical protein | - |
MRA_RS14200 | 2993821..2994054 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 2982519..2992786 | 10267 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T22180 WP_003899414.1 NC_009525:c2988877-2988554 [Mycobacterium tuberculosis H37Ra]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T22180 NC_009525:c2988877-2988554 [Mycobacterium tuberculosis H37Ra]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT22180 WP_003899415.1 NC_009525:c2989202-2988957 [Mycobacterium tuberculosis H37Ra]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT22180 NC_009525:c2989202-2988957 [Mycobacterium tuberculosis H37Ra]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045IHC4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A806JR81 |