Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1766745..1767499 | Replicon | chromosome |
| Accession | NZ_CP085812 | ||
| Organism | Salmonella enterica subsp. enterica serovar Schwarzengrund strain Articuno | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | LJF40_RS08315 | Protein ID | WP_000558166.1 |
| Coordinates | 1767188..1767499 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJF40_RS08310 | Protein ID | WP_001259009.1 |
| Coordinates | 1766745..1767191 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF40_RS08280 (LJF40_08280) | 1761921..1762817 | + | 897 | WP_001520529.1 | sugar kinase | - |
| LJF40_RS08285 (LJF40_08285) | 1762851..1763654 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LJF40_RS08290 (LJF40_08290) | 1763845..1764444 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LJF40_RS08295 (LJF40_08295) | 1764438..1765310 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LJF40_RS08300 (LJF40_08300) | 1765307..1765744 | + | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| LJF40_RS08305 (LJF40_08305) | 1765789..1766730 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LJF40_RS08310 (LJF40_08310) | 1766745..1767191 | - | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LJF40_RS08315 (LJF40_08315) | 1767188..1767499 | - | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LJF40_RS08320 (LJF40_08320) | 1767585..1768514 | - | 930 | WP_001127691.1 | alpha/beta hydrolase | - |
| LJF40_RS08325 (LJF40_08325) | 1768732..1769043 | + | 312 | WP_001159631.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| LJF40_RS08330 (LJF40_08330) | 1769044..1769334 | + | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| LJF40_RS08335 (LJF40_08335) | 1769381..1770310 | - | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| LJF40_RS08340 (LJF40_08340) | 1770307..1770942 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LJF40_RS08345 (LJF40_08345) | 1770939..1771841 | - | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T221787 WP_000558166.1 NZ_CP085812:c1767499-1767188 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T221787 NZ_CP117590:2419554-2419832 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGTTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
CCCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGTTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
CCCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT221787 WP_001259009.1 NZ_CP085812:c1767191-1766745 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT221787 NZ_CP117590:2419832-2420116 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGCTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGCTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|