Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 144030..144632 Replicon chromosome
Accession NZ_CP085811
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Zapdos

Toxin (Protein)


Gene name higB Uniprot ID A0A3V8XMR3
Locus tag LJF41_RS00705 Protein ID WP_001159631.1
Coordinates 144030..144341 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF41_RS00710 Protein ID WP_000362050.1
Coordinates 144342..144632 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF41_RS00670 (LJF41_00670) 139143..139742 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF41_RS00675 (LJF41_00675) 139736..140608 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF41_RS00680 (LJF41_00680) 140605..141042 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
LJF41_RS00685 (LJF41_00685) 141087..142028 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF41_RS00690 (LJF41_00690) 142043..142489 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF41_RS00695 (LJF41_00695) 142486..142797 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
LJF41_RS00700 (LJF41_00700) 142883..143812 - 930 WP_001127691.1 alpha/beta hydrolase -
LJF41_RS00705 (LJF41_00705) 144030..144341 + 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF41_RS00710 (LJF41_00710) 144342..144632 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF41_RS00715 (LJF41_00715) 144679..145608 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LJF41_RS00720 (LJF41_00720) 145605..146240 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF41_RS00725 (LJF41_00725) 146237..147139 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12312.25 Da        Isoelectric Point: 9.4460

>T221769 WP_001159631.1 NZ_CP085811:144030-144341 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221769 NZ_CP117586:1047748-1047900 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221769 WP_000362050.1 NZ_CP085811:144342-144632 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221769 NZ_CP117586:c1047703-1047655 [Escherichia albertii]
GTTCGAACGTAGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8XMR3

Antitoxin

Source ID Structure

References