Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3838658..3839260 Replicon chromosome
Accession NZ_CP085810
Organism Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres

Toxin (Protein)


Gene name higB Uniprot ID A0A3V8XMR3
Locus tag LJF42_RS18960 Protein ID WP_001159631.1
Coordinates 3838658..3838969 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF42_RS18965 Protein ID WP_000362050.1
Coordinates 3838970..3839260 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF42_RS18925 (LJF42_18925) 3833771..3834370 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF42_RS18930 (LJF42_18930) 3834364..3835236 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF42_RS18935 (LJF42_18935) 3835233..3835670 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
LJF42_RS18940 (LJF42_18940) 3835715..3836656 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF42_RS18945 (LJF42_18945) 3836671..3837117 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF42_RS18950 (LJF42_18950) 3837114..3837425 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
LJF42_RS18955 (LJF42_18955) 3837511..3838440 - 930 WP_001127691.1 alpha/beta hydrolase -
LJF42_RS18960 (LJF42_18960) 3838658..3838969 + 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF42_RS18965 (LJF42_18965) 3838970..3839260 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF42_RS18970 (LJF42_18970) 3839307..3840236 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LJF42_RS18975 (LJF42_18975) 3840233..3840868 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF42_RS18980 (LJF42_18980) 3840865..3841767 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12312.25 Da        Isoelectric Point: 9.4460

>T221764 WP_001159631.1 NZ_CP085810:3838658-3838969 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221764 NZ_CP117586:166995-167147 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221764 WP_000362050.1 NZ_CP085810:3838970-3839260 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221764 NZ_CP117586:c166938-166890 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8XMR3

Antitoxin

Source ID Structure

References