Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 3836671..3837425 | Replicon | chromosome |
| Accession | NZ_CP085810 | ||
| Organism | Salmonella enterica subsp. enterica serovar Schwarzengrund strain Moltres | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | LJF42_RS18950 | Protein ID | WP_000558166.1 |
| Coordinates | 3837114..3837425 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJF42_RS18945 | Protein ID | WP_001259009.1 |
| Coordinates | 3836671..3837117 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF42_RS18915 (LJF42_18915) | 3831847..3832743 | + | 897 | WP_001520529.1 | sugar kinase | - |
| LJF42_RS18920 (LJF42_18920) | 3832777..3833580 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LJF42_RS18925 (LJF42_18925) | 3833771..3834370 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LJF42_RS18930 (LJF42_18930) | 3834364..3835236 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LJF42_RS18935 (LJF42_18935) | 3835233..3835670 | + | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| LJF42_RS18940 (LJF42_18940) | 3835715..3836656 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LJF42_RS18945 (LJF42_18945) | 3836671..3837117 | - | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LJF42_RS18950 (LJF42_18950) | 3837114..3837425 | - | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LJF42_RS18955 (LJF42_18955) | 3837511..3838440 | - | 930 | WP_001127691.1 | alpha/beta hydrolase | - |
| LJF42_RS18960 (LJF42_18960) | 3838658..3838969 | + | 312 | WP_001159631.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| LJF42_RS18965 (LJF42_18965) | 3838970..3839260 | + | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| LJF42_RS18970 (LJF42_18970) | 3839307..3840236 | - | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| LJF42_RS18975 (LJF42_18975) | 3840233..3840868 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LJF42_RS18980 (LJF42_18980) | 3840865..3841767 | - | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T221763 WP_000558166.1 NZ_CP085810:c3837425-3837114 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T221763 NZ_CP117586:142848-143033 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT221763 WP_001259009.1 NZ_CP085810:c3837117-3836671 [Salmonella enterica subsp. enterica serovar Schwarzengrund]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT221763 NZ_CP117586:143050-143460 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|