Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 43542..44296 | Replicon | chromosome |
| Accession | NZ_CP085809 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain Raikou | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q8Z2U0 |
| Locus tag | LJF43_RS00210 | Protein ID | WP_000558160.1 |
| Coordinates | 43985..44296 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJF43_RS00205 | Protein ID | WP_001259009.1 |
| Coordinates | 43542..43988 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF43_RS00175 (LJF43_00175) | 38718..39614 | + | 897 | WP_001520529.1 | sugar kinase | - |
| LJF43_RS00180 (LJF43_00180) | 39648..40451 | + | 804 | WP_000059689.1 | DeoR family transcriptional regulator | - |
| LJF43_RS00185 (LJF43_00185) | 40642..41241 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LJF43_RS00190 (LJF43_00190) | 41235..42107 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LJF43_RS00195 (LJF43_00195) | 42104..42541 | + | 438 | WP_000560975.1 | D-aminoacyl-tRNA deacylase | - |
| LJF43_RS00200 (LJF43_00200) | 42586..43527 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LJF43_RS00205 (LJF43_00205) | 43542..43988 | - | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LJF43_RS00210 (LJF43_00210) | 43985..44296 | - | 312 | WP_000558160.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LJF43_RS00215 (LJF43_00215) | 44382..45311 | - | 930 | WP_001162859.1 | alpha/beta hydrolase | - |
| LJF43_RS00220 (LJF43_00220) | 45516..45758 | + | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| LJF43_RS00225 (LJF43_00225) | 45758..46132 | + | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJF43_RS00230 (LJF43_00230) | 46170..47099 | - | 930 | WP_000027727.1 | formate dehydrogenase accessory protein FdhE | - |
| LJF43_RS00235 (LJF43_00235) | 47096..47731 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LJF43_RS00240 (LJF43_00240) | 47728..48630 | - | 903 | WP_000331359.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12449.38 Da Isoelectric Point: 8.4020
>T221732 WP_000558160.1 NZ_CP085809:c44296-43985 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
Download Length: 312 bp
>T221732 NZ_CP117580:162841-163026 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT221732 WP_001259009.1 NZ_CP085809:c43988-43542 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT221732 NZ_CP117580:163043-163453 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|