Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4197142..4197896 | Replicon | chromosome |
| Accession | NZ_CP085808 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain Entei | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q8Z2U0 |
| Locus tag | LJF44_RS20745 | Protein ID | WP_000558160.1 |
| Coordinates | 4197142..4197453 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJF44_RS20750 | Protein ID | WP_001259009.1 |
| Coordinates | 4197450..4197896 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF44_RS20715 (LJF44_20720) | 4192808..4193710 | + | 903 | WP_000331359.1 | formate dehydrogenase subunit beta | - |
| LJF44_RS20720 (LJF44_20725) | 4193707..4194342 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LJF44_RS20725 (LJF44_20730) | 4194339..4195268 | + | 930 | WP_000027727.1 | formate dehydrogenase accessory protein FdhE | - |
| LJF44_RS20730 (LJF44_20735) | 4195306..4195680 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJF44_RS20735 (LJF44_20740) | 4195680..4195922 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| LJF44_RS20740 (LJF44_20745) | 4196127..4197056 | + | 930 | WP_001162859.1 | alpha/beta hydrolase | - |
| LJF44_RS20745 (LJF44_20750) | 4197142..4197453 | + | 312 | WP_000558160.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LJF44_RS20750 (LJF44_20755) | 4197450..4197896 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LJF44_RS20755 (LJF44_20760) | 4197911..4198852 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LJF44_RS20760 (LJF44_20765) | 4198897..4199334 | - | 438 | WP_000560975.1 | D-aminoacyl-tRNA deacylase | - |
| LJF44_RS20765 (LJF44_20770) | 4199331..4200203 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LJF44_RS20770 (LJF44_20775) | 4200197..4200796 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LJF44_RS20775 (LJF44_20780) | 4200987..4201790 | - | 804 | WP_000059689.1 | DeoR family transcriptional regulator | - |
| LJF44_RS20780 (LJF44_20785) | 4201824..4202720 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12449.38 Da Isoelectric Point: 8.4020
>T221730 WP_000558160.1 NZ_CP085808:4197142-4197453 [Salmonella enterica subsp. enterica serovar Typhi]
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
Download Length: 312 bp
>T221730 NZ_CP117576:64094-64492 [Escherichia albertii]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAAAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCTGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AGCGTAATCTCGCCGTGATCGAGGGATTTGTTTCCCGCCTTGATGTTCTGGATTACGACGCAACTGCAGCCACACACACC
GGTCAGATAAGAGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGTGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGCCTGAGAATTGAAGACTGGAGCTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAAAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCTGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AGCGTAATCTCGCCGTGATCGAGGGATTTGTTTCCCGCCTTGATGTTCTGGATTACGACGCAACTGCAGCCACACACACC
GGTCAGATAAGAGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGTGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGCCTGAGAATTGAAGACTGGAGCTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT221730 WP_001259009.1 NZ_CP085808:4197450-4197896 [Salmonella enterica subsp. enterica serovar Typhi]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT221730 NZ_CP117576:63867-64094 [Escherichia albertii]
ATGGAAACTACCGTATTTCTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTACCGGAAAACGTAAA
ACGTGTTGAAGTGATTGCTGTCGGACGAGCCCGAATCATTACGCCCGCCGGAGAGACATGGGATGAATGGTTCGACGGAA
ACAGCGTCAGCGCCGATTTTATGGATAACAGGGAACAGTCCGACATGCAGGAAAGGGAGTCATTCTGA
ATGGAAACTACCGTATTTCTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTACCGGAAAACGTAAA
ACGTGTTGAAGTGATTGCTGTCGGACGAGCCCGAATCATTACGCCCGCCGGAGAGACATGGGATGAATGGTTCGACGGAA
ACAGCGTCAGCGCCGATTTTATGGATAACAGGGAACAGTCCGACATGCAGGAAAGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|