Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4752877..4753631 | Replicon | chromosome |
| Accession | NZ_CP085807 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain Suicune | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q8Z2U0 |
| Locus tag | LJF45_RS23390 | Protein ID | WP_000558160.1 |
| Coordinates | 4752877..4753188 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJF45_RS23395 | Protein ID | WP_001259009.1 |
| Coordinates | 4753185..4753631 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF45_RS23360 (LJF45_23365) | 4748543..4749445 | + | 903 | WP_000331359.1 | formate dehydrogenase subunit beta | - |
| LJF45_RS23365 (LJF45_23370) | 4749442..4750077 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LJF45_RS23370 (LJF45_23375) | 4750074..4751003 | + | 930 | WP_000027727.1 | formate dehydrogenase accessory protein FdhE | - |
| LJF45_RS23375 (LJF45_23380) | 4751041..4751415 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| LJF45_RS23380 (LJF45_23385) | 4751415..4751657 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| LJF45_RS23385 (LJF45_23390) | 4751862..4752791 | + | 930 | WP_001162859.1 | alpha/beta hydrolase | - |
| LJF45_RS23390 (LJF45_23395) | 4752877..4753188 | + | 312 | WP_000558160.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LJF45_RS23395 (LJF45_23400) | 4753185..4753631 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LJF45_RS23400 (LJF45_23405) | 4753646..4754587 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LJF45_RS23405 (LJF45_23410) | 4754632..4755069 | - | 438 | WP_000560975.1 | D-aminoacyl-tRNA deacylase | - |
| LJF45_RS23410 (LJF45_23415) | 4755066..4755938 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LJF45_RS23415 (LJF45_23420) | 4755932..4756531 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LJF45_RS23420 (LJF45_23425) | 4756722..4757525 | - | 804 | WP_000059689.1 | DeoR family transcriptional regulator | - |
| LJF45_RS23425 (LJF45_23430) | 4757559..4758455 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12449.38 Da Isoelectric Point: 8.4020
>T221712 WP_000558160.1 NZ_CP085807:4752877-4753188 [Salmonella enterica subsp. enterica serovar Typhi]
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
VHVISRKLFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
Download Length: 312 bp
>T221712 NZ_CP117575:c595344-595066 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTAATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGTAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTAATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGTAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT221712 WP_001259009.1 NZ_CP085807:4753185-4753631 [Salmonella enterica subsp. enterica serovar Typhi]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT221712 NZ_CP117575:c595066-594782 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTAACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTAACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTGACGCAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|