Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4600829..4601431 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag LJF46_RS22455 Protein ID WP_001159635.1
Coordinates 4600829..4601140 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF46_RS22460 Protein ID WP_000362050.1
Coordinates 4601141..4601431 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS22420 (4595942) 4595942..4596541 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF46_RS22425 (4596535) 4596535..4597407 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF46_RS22430 (4597404) 4597404..4597841 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF46_RS22435 (4597886) 4597886..4598827 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF46_RS22440 (4598842) 4598842..4599288 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF46_RS22445 (4599285) 4599285..4599596 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
LJF46_RS22450 (4599682) 4599682..4600611 - 930 WP_001127705.1 alpha/beta hydrolase -
LJF46_RS22455 (4600829) 4600829..4601140 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF46_RS22460 (4601141) 4601141..4601431 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF46_RS22465 (4601478) 4601478..4602407 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF46_RS22470 (4602404) 4602404..4603039 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF46_RS22475 (4603036) 4603036..4603938 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T221693 WP_001159635.1 NZ_CP085806:4600829-4601140 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221693 NZ_CP117568:c3758396-3758244 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221693 WP_000362050.1 NZ_CP085806:4601141-4601431 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221693 NZ_CP117568:3758445-3758502 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References