Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4050864..4051402 Replicon chromosome
Accession NZ_CP085806
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag LJF46_RS19905 Protein ID WP_001526148.1
Coordinates 4050864..4051139 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag LJF46_RS19910 Protein ID WP_000729713.1
Coordinates 4051142..4051402 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF46_RS19900 (4048071) 4048071..4050776 + 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -
LJF46_RS19905 (4050864) 4050864..4051139 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
LJF46_RS19910 (4051142) 4051142..4051402 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF46_RS19915 (4051511) 4051511..4052530 - 1020 WP_000101024.1 RNA 3'-terminal phosphate cyclase -
LJF46_RS19920 (4052534) 4052534..4053748 - 1215 WP_001105533.1 RNA-splicing ligase RtcB -
LJF46_RS19925 (4054096) 4054096..4055649 - 1554 WP_000013013.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T221689 WP_001526148.1 NZ_CP085806:c4051139-4050864 [Salmonella enterica subsp. enterica serovar Enteritidis]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T221689 NZ_CP117568:2654119-2654409 [Escherichia albertii]
ATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAAGATACCTTCTGA
TATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACGACCTGGAAGGACTTGAGATCACCACCAGGTA
ATCGGTATGAGGAATTGTCAGGGAAGCTAAACTGCTATTCATCAATAAGGGTGAATAATCAATATAGGTTAATTTTTAAG
TGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT221689 WP_000729713.1 NZ_CP085806:c4051402-4051142 [Salmonella enterica subsp. enterica serovar Enteritidis]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT221689 NZ_CP117568:2654481-2654819 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References