Detailed information of TA system TA221684

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1932243..1932468
• Replicon: chromosome
• Accession: NZ_CP085806
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Marill

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF46_RS09410
• Protein ID: WP_000813254.1
• Coordinates: 1932313..1932468 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1932243..1932301 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF46_RS09370	1927344..1927565	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF46_RS09375	1928003..1928524	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF46_RS09380	1928632..1928787	-	156	WP_085981757.1	DUF1391 family protein	-
LJF46_RS09385	1929172..1929639	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF46_RS22990	1929821..1929868	+	48	Protein_1819	hypothetical protein	-
LJF46_RS09395	1929912..1930241	+	330	WP_001676916.1	DUF977 family protein	-
LJF46_RS09400	1930403..1930957	-	555	WP_001033796.1	hypothetical protein	-
LJF46_RS09405	1930954..1931886	-	933	WP_000556390.1	hypothetical protein	-
-	1932243..1932301	-	59	-	-	Antitoxin
LJF46_RS09410	1932313..1932468	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF46_RS09415	1932759..1932929	+	171	WP_000734094.1	hypothetical protein	-
LJF46_RS09420	1932992..1933591	+	600	WP_000940751.1	DUF1367 family protein	-
LJF46_RS09425	1933591..1933881	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF46_RS09430	1933878..1934414	+	537	WP_000640113.1	DUF1133 family protein	-
LJF46_RS09435	1936585..1936908	+	324	Protein_1828	tellurite/colicin resistance protein	-
LJF46_RS09440	1936902..1937090	+	189	WP_001688615.1	putative holin	-
LJF46_RS09445	1937080..1937361	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1926032..1937903	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221684 WP_000813254.1 NZ_CP085806:1932313-1932468 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221684 NZ_CP117568:c1856786-1856634 [Escherichia albertii]
ATGCTGACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTTCACGGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT221684 NZ_CP085806:c1932301-1932243 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin