Detailed information of TA system TA221650

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2786615..2786840
• Replicon: chromosome
• Accession: NZ_CP085805
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF48_RS13590
• Protein ID: WP_000813254.1
• Coordinates: 2786615..2786770 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2786782..2786840 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF48_RS13555	2781722..2782003	-	282	WP_000445513.1	phage holin family protein	-
LJF48_RS13560	2781993..2782181	-	189	WP_001688615.1	putative holin	-
LJF48_RS13565	2782175..2782498	-	324	Protein_2643	tellurite/colicin resistance protein	-
LJF48_RS13570	2784669..2785205	-	537	WP_000640113.1	DUF1133 family protein	-
LJF48_RS13575	2785202..2785492	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF48_RS13580	2785492..2786091	-	600	WP_000940751.1	DUF1367 family protein	-
LJF48_RS13585	2786154..2786324	-	171	WP_000734094.1	hypothetical protein	-
LJF48_RS13590	2786615..2786770	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2786782..2786840	+	59	-	-	Antitoxin
LJF48_RS13595	2787197..2788129	+	933	WP_000556390.1	hypothetical protein	-
LJF48_RS13600	2788126..2788680	+	555	WP_001033796.1	hypothetical protein	-
LJF48_RS13605	2788842..2789171	-	330	WP_001676916.1	DUF977 family protein	-
LJF48_RS23000	2789215..2789262	-	48	Protein_2652	hypothetical protein	-
LJF48_RS13615	2789444..2789911	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF48_RS13620	2790296..2790451	+	156	WP_085981757.1	DUF1391 family protein	-
LJF48_RS13625	2790559..2791080	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF48_RS13630	2791518..2791739	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2781180..2816645	35465

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221650 WP_000813254.1 NZ_CP085805:c2786770-2786615 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221650 NZ_CP117559:29908-30213 [Escherichia albertii]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221650 NZ_CP085805:2786782-2786840 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin