Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 119486..120240 Replicon chromosome
Accession NZ_CP085805
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Azumarill

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF48_RS00550 Protein ID WP_000558168.1
Coordinates 119486..119797 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF48_RS00555 Protein ID WP_001259009.1
Coordinates 119794..120240 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF48_RS00520 (115144) 115144..116046 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LJF48_RS00525 (116043) 116043..116678 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF48_RS00530 (116675) 116675..117604 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF48_RS00535 (117651) 117651..117941 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF48_RS00540 (117942) 117942..118253 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF48_RS00545 (118471) 118471..119400 + 930 WP_001127705.1 alpha/beta hydrolase -
LJF48_RS00550 (119486) 119486..119797 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF48_RS00555 (119794) 119794..120240 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF48_RS00560 (120255) 120255..121196 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF48_RS00565 (121241) 121241..121678 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF48_RS00570 (121675) 121675..122547 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF48_RS00575 (122541) 122541..123140 - 600 WP_000965695.1 glucose-1-phosphatase -
LJF48_RS00580 (123331) 123331..124134 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF48_RS00585 (124168) 124168..125064 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T221643 WP_000558168.1 NZ_CP085805:119486-119797 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T221643 NZ_CP117558:c2873807-2873652 [Escherichia albertii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT221643 WP_001259009.1 NZ_CP085805:119794-120240 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT221643 NZ_CP117558:2873819-2873877 [Escherichia albertii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2S541

Antitoxin

Source ID Structure

References