Detailed information of TA system TA221617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 45847..46449
• Replicon: chromosome
• Accession: NZ_CP085804
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Leafeon

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LJF49_RS00225
• Protein ID: WP_001159635.1
• Coordinates: 45847..46158 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LJF49_RS00230
• Protein ID: WP_000362050.1
• Coordinates: 46159..46449 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF49_RS00190 (40960)	40960..41559	+	600	WP_000965695.1	glucose-1-phosphatase	-
LJF49_RS00195 (41553)	41553..42425	+	873	WP_000921423.1	virulence factor BrkB family protein	-
LJF49_RS00200 (42422)	42422..42859	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LJF49_RS00205 (42904)	42904..43845	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LJF49_RS00210 (43860)	43860..44306	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LJF49_RS00215 (44303)	44303..44614	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LJF49_RS00220 (44700)	44700..45629	-	930	WP_001127705.1	alpha/beta hydrolase	-
LJF49_RS00225 (45847)	45847..46158	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LJF49_RS00230 (46159)	46159..46449	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LJF49_RS00235 (46496)	46496..47425	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
LJF49_RS00240 (47422)	47422..48057	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LJF49_RS00245 (48054)	48054..48956	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T221617 WP_001159635.1 NZ_CP085804:45847-46158 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T221617 NZ_CP117556:661554-661868 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCTGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT221617 WP_000362050.1 NZ_CP085804:46159-46449 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT221617 NZ_CP117556:661865-662281 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCTCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97