Detailed information of TA system TA221608

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2185410..2185635
• Replicon: chromosome
• Accession: NZ_CP085803
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Glaceon

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF50_RS10625
• Protein ID: WP_000813254.1
• Coordinates: 2185480..2185635 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2185410..2185468 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF50_RS10585	2180511..2180732	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF50_RS10590	2181170..2181691	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF50_RS10595	2181799..2181954	-	156	WP_085981757.1	DUF1391 family protein	-
LJF50_RS10600	2182339..2182806	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF50_RS23005	2182988..2183035	+	48	Protein_2048	hypothetical protein	-
LJF50_RS10610	2183079..2183408	+	330	WP_001676916.1	DUF977 family protein	-
LJF50_RS10615	2183570..2184124	-	555	WP_001033796.1	hypothetical protein	-
LJF50_RS10620	2184121..2185053	-	933	WP_000556390.1	hypothetical protein	-
-	2185410..2185468	-	59	-	-	Antitoxin
LJF50_RS10625	2185480..2185635	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF50_RS10630	2185926..2186096	+	171	WP_000734094.1	hypothetical protein	-
LJF50_RS10635	2186159..2186758	+	600	WP_000940751.1	DUF1367 family protein	-
LJF50_RS10640	2186758..2187048	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF50_RS10645	2187045..2187581	+	537	WP_000640113.1	DUF1133 family protein	-
LJF50_RS10650	2189752..2190075	+	324	Protein_2057	tellurite/colicin resistance protein	-
LJF50_RS10655	2190069..2190257	+	189	WP_001688615.1	putative holin	-
LJF50_RS10660	2190247..2190528	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2181170..2191070	9900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221608 WP_000813254.1 NZ_CP085803:2185480-2185635 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221608 NZ_CP117554:725899-726318 [Erwinia amylovora]
GTGGTCCTGTGGCAATGTGAACTGCGGCCATCAAGGCTGGCACAGCGGTTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTATTGCCGACATGGCCCGCCAGCTCTGGCCTGGTGCGGATGCTGTTGCTGGTTTTGGTACTGTTGGAGTGCA
TACGCAGTCGGCGGCGCATTGGTCGTCGCCAGGGGGATATCGCTCTGTTGGAAGGGCATGAGCTACGCTGGCGTCAACGC
GAGTGGTGCATTATTTCCCGTCCGTGGCTGACCGGGCAGGCAATCCTGCTGTTACTACAGGATACTCATGGACAGCGCGA
GCGACTATGGCTGTTCGCCGACGGCATGGAAAAACGTAACTGGCGTCAGCTGCGCCTGCAATTGCTGAACAGTAAAGTAC
AGGGGAATGGCTGGTGCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221608 NZ_CP085803:c2185468-2185410 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin