Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4056440..4057042 Replicon chromosome
Accession NZ_CP085802
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Wailmer

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag LJF51_RS19845 Protein ID WP_001159635.1
Coordinates 4056731..4057042 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF51_RS19840 Protein ID WP_000362050.1
Coordinates 4056440..4056730 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF51_RS19825 (4053933) 4053933..4054835 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
LJF51_RS19830 (4054832) 4054832..4055467 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF51_RS19835 (4055464) 4055464..4056393 + 930 WP_227798835.1 formate dehydrogenase accessory protein FdhE -
LJF51_RS19840 (4056440) 4056440..4056730 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF51_RS19845 (4056731) 4056731..4057042 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF51_RS19850 (4057260) 4057260..4058189 + 930 WP_001127705.1 alpha/beta hydrolase -
LJF51_RS19855 (4058275) 4058275..4058586 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
LJF51_RS19860 (4058583) 4058583..4059029 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF51_RS19865 (4059044) 4059044..4059985 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF51_RS19870 (4060030) 4060030..4060467 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF51_RS19875 (4060464) 4060464..4061336 - 873 WP_000921423.1 virulence factor BrkB family protein -
LJF51_RS19880 (4061330) 4061330..4061929 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T221585 WP_001159635.1 NZ_CP085802:c4057042-4056731 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221585 NZ_CP117511:526117-526233 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221585 WP_000362050.1 NZ_CP085802:c4056730-4056440 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221585 NZ_CP117511:c526349-526144 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References