Detailed information of TA system TA221541

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2011884..2012109
• Replicon: chromosome
• Accession: NZ_CP085801
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Wailord

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF52_RS09920
• Protein ID: WP_000813254.1
• Coordinates: 2011884..2012039 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2012051..2012109 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF52_RS09885	2006991..2007272	-	282	WP_000445513.1	phage holin family protein	-
LJF52_RS09890	2007262..2007450	-	189	WP_001688615.1	putative holin	-
LJF52_RS09895	2007444..2007767	-	324	Protein_1933	tellurite/colicin resistance protein	-
LJF52_RS09900	2009938..2010474	-	537	WP_000640113.1	DUF1133 family protein	-
LJF52_RS09905	2010471..2010761	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF52_RS09910	2010761..2011360	-	600	WP_000940751.1	DUF1367 family protein	-
LJF52_RS09915	2011423..2011593	-	171	WP_000734094.1	hypothetical protein	-
LJF52_RS09920	2011884..2012039	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2012051..2012109	+	59	-	-	Antitoxin
LJF52_RS09925	2012466..2013398	+	933	WP_000556390.1	hypothetical protein	-
LJF52_RS09930	2013395..2013949	+	555	WP_001033796.1	hypothetical protein	-
LJF52_RS09935	2014111..2014440	-	330	WP_001676916.1	DUF977 family protein	-
LJF52_RS22990	2014484..2014531	-	48	Protein_1942	hypothetical protein	-
LJF52_RS09945	2014713..2015180	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF52_RS09950	2015565..2015720	+	156	WP_085981757.1	DUF1391 family protein	-
LJF52_RS09955	2015828..2016349	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF52_RS09960	2016787..2017008	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2006449..2018320	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221541 WP_000813254.1 NZ_CP085801:c2012039-2011884 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221541 NZ_CP117471:2006437-2006952 [Sphingobium sp. YC-XJ3]
GTGGCGGACATCCGCATCACGCCACCCGCGCGTCTGACCGCCGATCACGATGTCGCGGGCTTCGCCAATGGCGTGCATGC
CTCGCTCGATGACTGGCTGCGGGACCGCGCGCTGGCGAGCGAGGGGAGTTCGGCGCGCACCTATGTCGTCTGCAATGCCG
CCGAGCCGCGCCGGGTGGTCGGCTACTATACGATCACGACCGCGATGGAGCAGCGGGCTGCTCTGCCGTCCGCGAAGCTG
CGGCGCGGCATGCCCGACCGGGTGCCGCTGCTCCTGATCGGCCGGCTCGCCGTTGATGCCGGGTTCCAGGGCATCGGCCT
TGGCGCCGATCTTCTGGCCGATGCGCTCCGGCGCTGCGCCGCGGCAGCCGAGATTGCCGGTGCGCGCGCGGTGATCGTTC
ATGCGATCGACGAAAAGGCGGCGGCGTTTTATGCGCGGCACGGGTTTATCCCTACCTCGCTCGGCGAACTGGTCATGCTG
CTGCCGATCGAGGCAATCCGCTCGCGGCCGAACTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221541 NZ_CP085801:2012051-2012109 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin