Detailed information of TA system TA221486

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1278296..1278521
• Replicon: chromosome
• Accession: NZ_CP085799
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Swellow

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF54_RS06325
• Protein ID: WP_000813254.1
• Coordinates: 1278296..1278451 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1278463..1278521 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF54_RS06290	1273403..1273684	-	282	WP_000445513.1	phage holin family protein	-
LJF54_RS06295	1273674..1273862	-	189	WP_001688615.1	putative holin	-
LJF54_RS06300	1273856..1274179	-	324	Protein_1236	tellurite/colicin resistance protein	-
LJF54_RS06305	1276350..1276886	-	537	WP_000640113.1	DUF1133 family protein	-
LJF54_RS06310	1276883..1277173	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF54_RS06315	1277173..1277772	-	600	WP_000940751.1	DUF1367 family protein	-
LJF54_RS06320	1277835..1278005	-	171	WP_000734094.1	hypothetical protein	-
LJF54_RS06325	1278296..1278451	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1278463..1278521	+	59	-	-	Antitoxin
LJF54_RS06330	1278878..1279810	+	933	WP_000556390.1	hypothetical protein	-
LJF54_RS06335	1279807..1280361	+	555	WP_001033796.1	hypothetical protein	-
LJF54_RS06340	1280523..1280852	-	330	WP_001676916.1	DUF977 family protein	-
LJF54_RS23005	1280896..1280943	-	48	Protein_1245	hypothetical protein	-
LJF54_RS06350	1281125..1281592	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF54_RS06355	1281977..1282132	+	156	WP_085981757.1	DUF1391 family protein	-
LJF54_RS06360	1282240..1282761	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF54_RS06365	1283199..1283420	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1272861..1284732	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221486 WP_000813254.1 NZ_CP085799:c1278451-1278296 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221486 NZ_CP117398:4718561-4718872 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221486 NZ_CP085799:1278463-1278521 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin