Detailed information of TA system TA221463

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2011850..2012075
• Replicon: chromosome
• Accession: NZ_CP085798
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Latias

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF55_RS09910
• Protein ID: WP_000813254.1
• Coordinates: 2011850..2012005 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2012017..2012075 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF55_RS09875	2006957..2007238	-	282	WP_000445513.1	phage holin family protein	-
LJF55_RS09880	2007228..2007416	-	189	WP_001688615.1	putative holin	-
LJF55_RS09885	2007410..2007733	-	324	Protein_1931	tellurite/colicin resistance protein	-
LJF55_RS09890	2009904..2010440	-	537	WP_000640113.1	DUF1133 family protein	-
LJF55_RS09895	2010437..2010727	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF55_RS09900	2010727..2011326	-	600	WP_000940751.1	DUF1367 family protein	-
LJF55_RS09905	2011389..2011559	-	171	WP_000734094.1	hypothetical protein	-
LJF55_RS09910	2011850..2012005	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2012017..2012075	+	59	-	-	Antitoxin
LJF55_RS09915	2012432..2013364	+	933	WP_000556390.1	hypothetical protein	-
LJF55_RS09920	2013361..2013915	+	555	WP_001033796.1	hypothetical protein	-
LJF55_RS09925	2014077..2014406	-	330	WP_001676916.1	DUF977 family protein	-
LJF55_RS22980	2014450..2014497	-	48	Protein_1940	hypothetical protein	-
LJF55_RS09935	2014679..2015146	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF55_RS09940	2015531..2015686	+	156	WP_085981757.1	DUF1391 family protein	-
LJF55_RS09945	2015794..2016315	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF55_RS09950	2016753..2016974	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2006415..2018286	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221463 WP_000813254.1 NZ_CP085798:c2012005-2011850 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221463 NZ_CP117396:3487240-3487458 [Salmonella enterica subsp. enterica serovar Uganda]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221463 NZ_CP085798:2012017-2012075 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin