Detailed information of TA system TA221446

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3537384..3537609
• Replicon: chromosome
• Accession: NZ_CP085797
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF56_RS17025
• Protein ID: WP_000813254.1
• Coordinates: 3537384..3537539 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3537551..3537609 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF56_RS16990	3532491..3532772	-	282	WP_000445513.1	phage holin family protein	-
LJF56_RS16995	3532762..3532950	-	189	WP_001688615.1	putative holin	-
LJF56_RS17000	3532944..3533267	-	324	Protein_3308	tellurite/colicin resistance protein	-
LJF56_RS17005	3535438..3535974	-	537	WP_000640113.1	DUF1133 family protein	-
LJF56_RS17010	3535971..3536261	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF56_RS17015	3536261..3536860	-	600	WP_000940751.1	DUF1367 family protein	-
LJF56_RS17020	3536923..3537093	-	171	WP_000734094.1	hypothetical protein	-
LJF56_RS17025	3537384..3537539	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3537551..3537609	+	59	-	-	Antitoxin
LJF56_RS17030	3537966..3538898	+	933	WP_000556390.1	hypothetical protein	-
LJF56_RS17035	3538895..3539449	+	555	WP_001033796.1	hypothetical protein	-
LJF56_RS17040	3539611..3539940	-	330	WP_001676916.1	DUF977 family protein	-
LJF56_RS22990	3539984..3540031	-	48	Protein_3317	hypothetical protein	-
LJF56_RS17050	3540213..3540680	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF56_RS17055	3541065..3541220	+	156	WP_085981757.1	DUF1391 family protein	-
LJF56_RS17060	3541328..3541849	-	522	WP_000004762.1	super-infection exclusion protein B	-
LJF56_RS17065	3542287..3542508	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3531949..3543820	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221446 WP_000813254.1 NZ_CP085797:c3537539-3537384 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221446 NZ_CP117394:2369562-2369846 [Salmonella enterica subsp. enterica serovar Uganda]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAGCTGGGACATACTATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGCGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221446 NZ_CP085797:3537551-3537609 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin