Detailed information of TA system TA221438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 868430..869032
• Replicon: chromosome
• Accession: NZ_CP085797
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Latios

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LJF56_RS03985
• Protein ID: WP_001159635.1
• Coordinates: 868721..869032 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LJF56_RS03980
• Protein ID: WP_000362050.1
• Coordinates: 868430..868720 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF56_RS03965 (865923)	865923..866825	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
LJF56_RS03970 (866822)	866822..867457	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LJF56_RS03975 (867454)	867454..868383	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
LJF56_RS03980 (868430)	868430..868720	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LJF56_RS03985 (868721)	868721..869032	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LJF56_RS03990 (869250)	869250..870179	+	930	WP_001127705.1	alpha/beta hydrolase	-
LJF56_RS03995 (870265)	870265..870576	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LJF56_RS04000 (870573)	870573..871019	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LJF56_RS04005 (871034)	871034..871975	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LJF56_RS04010 (872020)	872020..872457	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LJF56_RS04015 (872454)	872454..873326	-	873	WP_000921423.1	virulence factor BrkB family protein	-
LJF56_RS04020 (873320)	873320..873919	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T221438 WP_001159635.1 NZ_CP085797:c869032-868721 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T221438 NZ_CP117392:c4451737-4451426 [Salmonella enterica subsp. enterica serovar Give]
ATGCAATTCATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGCAGTGGCGTACGAATTATCTATTTTCATCGTAGTCAACGGTATGAGGTTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT221438 WP_000362050.1 NZ_CP085797:c868720-868430 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT221438 NZ_CP117392:c4451425-4451135 [Salmonella enterica subsp. enterica serovar Give]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97