221408

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 111668..112206 Replicon chromosome
Accession NZ_CP085796
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Froakie

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag LJF57_RS00605 Protein ID WP_001526148.1
Coordinates 111668..111943 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag LJF57_RS00610 Protein ID WP_000729713.1
Coordinates 111946..112206 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF57_RS00600 (108875) 108875..111580 + 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -
LJF57_RS00605 (111668) 111668..111943 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
LJF57_RS00610 (111946) 111946..112206 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJF57_RS00615 (112315) 112315..113334 - 1020 WP_000101024.1 RNA 3'-terminal phosphate cyclase -
LJF57_RS00620 (113338) 113338..114552 - 1215 WP_001105533.1 RNA-splicing ligase RtcB -
LJF57_RS00625 (114900) 114900..116453 - 1554 WP_000013013.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T221408 WP_001526148.1 NZ_CP085796:c111943-111668 [Salmonella enterica subsp. enterica serovar Enteritidis]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T221408 NZ_CP117388:3690699-3690956 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCACCTTAAGGGTGACTGGCTGGAAGAAGCGGGATTTGAGACCGGGCGCGGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT221408 WP_000729713.1 NZ_CP085796:c112206-111946 [Salmonella enterica subsp. enterica serovar Enteritidis]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT221408 NZ_CP117388:c3690874-3690606 [Salmonella enterica subsp. enterica serovar Uganda]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References