Detailed information of TA system TA221406

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3406859..3407084
• Replicon: chromosome
• Accession: NZ_CP085795
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF59_RS16440
• Protein ID: WP_000813254.1
• Coordinates: 3406929..3407084 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3406859..3406917 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF59_RS16400	3401960..3402181	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF59_RS16405	3402619..3403140	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF59_RS16410	3403248..3403403	-	156	WP_085981757.1	DUF1391 family protein	-
LJF59_RS16415	3403788..3404255	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF59_RS22770	3404437..3404484	+	48	Protein_3180	hypothetical protein	-
LJF59_RS16425	3404528..3404857	+	330	WP_001676916.1	DUF977 family protein	-
LJF59_RS16430	3405019..3405573	-	555	WP_001033796.1	hypothetical protein	-
LJF59_RS16435	3405570..3406502	-	933	WP_000556390.1	hypothetical protein	-
-	3406859..3406917	-	59	-	-	Antitoxin
LJF59_RS16440	3406929..3407084	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF59_RS16445	3407375..3407545	+	171	WP_000734094.1	hypothetical protein	-
LJF59_RS16450	3407608..3408207	+	600	WP_000940751.1	DUF1367 family protein	-
LJF59_RS16455	3408207..3408497	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF59_RS16460	3408494..3409030	+	537	WP_000640113.1	DUF1133 family protein	-
LJF59_RS16465	3411201..3411524	+	324	Protein_3189	tellurite/colicin resistance protein	-
LJF59_RS16470	3411518..3411706	+	189	WP_001688615.1	putative holin	-
LJF59_RS16475	3411696..3411977	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3400648..3412519	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221406 WP_000813254.1 NZ_CP085795:3406929-3407084 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221406 NZ_CP117388:3685370-3685627 [Salmonella enterica subsp. enterica serovar Uganda]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGTCCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCATCACCGTGAAGATTTCACAGGAGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAACAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT221406 NZ_CP085795:c3406917-3406859 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin