Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1359868..1360622 | Replicon | chromosome |
| Accession | NZ_CP085795 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain Frogadier | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | LJF59_RS06510 | Protein ID | WP_000558168.1 |
| Coordinates | 1360311..1360622 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJF59_RS06505 | Protein ID | WP_001259009.1 |
| Coordinates | 1359868..1360314 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF59_RS06475 (1355044) | 1355044..1355940 | + | 897 | WP_001520529.1 | sugar kinase | - |
| LJF59_RS06480 (1355974) | 1355974..1356777 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| LJF59_RS06485 (1356968) | 1356968..1357567 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| LJF59_RS06490 (1357561) | 1357561..1358433 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LJF59_RS06495 (1358430) | 1358430..1358867 | + | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| LJF59_RS06500 (1358912) | 1358912..1359853 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LJF59_RS06505 (1359868) | 1359868..1360314 | - | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LJF59_RS06510 (1360311) | 1360311..1360622 | - | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LJF59_RS06515 (1360708) | 1360708..1361637 | - | 930 | WP_001127705.1 | alpha/beta hydrolase | - |
| LJF59_RS06520 (1361855) | 1361855..1362166 | + | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| LJF59_RS06525 (1362167) | 1362167..1362457 | + | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| LJF59_RS06530 (1362504) | 1362504..1363433 | - | 930 | WP_000027736.1 | formate dehydrogenase accessory protein FdhE | - |
| LJF59_RS06535 (1363430) | 1363430..1364065 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LJF59_RS06540 (1364062) | 1364062..1364964 | - | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T221388 WP_000558168.1 NZ_CP085795:c1360622-1360311 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T221388 NZ_CP117386:c2591944-2591591 [Salmonella enterica subsp. enterica serovar Uganda]
GTGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAACGATACCAACAGGGTCAGCGTGCTTGC
AGCACTGCTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGGTCAGAGGTTCCCGTTACAGCA
ACATGAAAGAGCTACGTATTCAGAGTCGGGGCGAGCCGATACGGGCGTTTTTCGCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGTAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
GAACTGGCTGAACACATTAAAAGAGAAGGAGTAA
GTGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAACGATACCAACAGGGTCAGCGTGCTTGC
AGCACTGCTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGGTCAGAGGTTCCCGTTACAGCA
ACATGAAAGAGCTACGTATTCAGAGTCGGGGCGAGCCGATACGGGCGTTTTTCGCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGTAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
GAACTGGCTGAACACATTAAAAGAGAAGGAGTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT221388 WP_001259009.1 NZ_CP085795:c1360314-1359868 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT221388 NZ_CP117386:c2591586-2591284 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAGAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACA
GGCGGCAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAGAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACA
GGCGGCAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|