Detailed information of TA system TA221380

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3406646..3406871
• Replicon: chromosome
• Accession: NZ_CP085794
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF60_RS16435
• Protein ID: WP_000813254.1
• Coordinates: 3406716..3406871 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3406646..3406704 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF60_RS16395	3401747..3401968	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF60_RS16400	3402406..3402927	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF60_RS16405	3403035..3403190	-	156	WP_085981757.1	DUF1391 family protein	-
LJF60_RS16410	3403575..3404042	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF60_RS22765	3404224..3404271	+	48	Protein_3180	hypothetical protein	-
LJF60_RS16420	3404315..3404644	+	330	WP_001676916.1	DUF977 family protein	-
LJF60_RS16425	3404806..3405360	-	555	WP_001033796.1	hypothetical protein	-
LJF60_RS16430	3405357..3406289	-	933	WP_000556390.1	hypothetical protein	-
-	3406646..3406704	-	59	-	-	Antitoxin
LJF60_RS16435	3406716..3406871	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF60_RS16440	3407162..3407332	+	171	WP_000734094.1	hypothetical protein	-
LJF60_RS16445	3407395..3407994	+	600	WP_000940751.1	DUF1367 family protein	-
LJF60_RS16450	3407994..3408284	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF60_RS16455	3408281..3408817	+	537	WP_000640113.1	DUF1133 family protein	-
LJF60_RS16460	3410988..3411311	+	324	Protein_3189	tellurite/colicin resistance protein	-
LJF60_RS16465	3411305..3411493	+	189	WP_001688615.1	putative holin	-
LJF60_RS16470	3411483..3411764	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3400435..3412306	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221380 WP_000813254.1 NZ_CP085794:3406716-3406871 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221380 NZ_CP085794:3406716-3406871 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221380 NZ_CP085794:c3406704-3406646 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin