Detailed information of TA system TA221363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 1361734..1362336
• Replicon: chromosome
• Accession: NZ_CP085794
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: LJF60_RS06515
• Protein ID: WP_001159635.1
• Coordinates: 1361734..1362045 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LJF60_RS06520
• Protein ID: WP_000362050.1
• Coordinates: 1362046..1362336 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF60_RS06480 (1356847)	1356847..1357446	+	600	WP_000965695.1	glucose-1-phosphatase	-
LJF60_RS06485 (1357440)	1357440..1358312	+	873	WP_000921423.1	virulence factor BrkB family protein	-
LJF60_RS06490 (1358309)	1358309..1358746	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
LJF60_RS06495 (1358791)	1358791..1359732	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LJF60_RS06500 (1359747)	1359747..1360193	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
LJF60_RS06505 (1360190)	1360190..1360501	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
LJF60_RS06510 (1360587)	1360587..1361516	-	930	WP_001127705.1	alpha/beta hydrolase	-
LJF60_RS06515 (1361734)	1361734..1362045	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LJF60_RS06520 (1362046)	1362046..1362336	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LJF60_RS06525 (1362383)	1362383..1363312	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
LJF60_RS06530 (1363309)	1363309..1363944	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LJF60_RS06535 (1363941)	1363941..1364843	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T221363 WP_001159635.1 NZ_CP085794:1361734-1362045 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T221363 NZ_CP117382:c4614256-4613945 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT221363 WP_000362050.1 NZ_CP085794:1362046-1362336 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT221363 NZ_CP117382:c4613944-4613654 [Salmonella enterica subsp. enterica serovar Uganda]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97