Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1359747..1360501 Replicon chromosome
Accession NZ_CP085794
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Greninja

Toxin (Protein)


Gene name higB Uniprot ID B5RFE2
Locus tag LJF60_RS06505 Protein ID WP_000558168.1
Coordinates 1360190..1360501 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF60_RS06500 Protein ID WP_001259009.1
Coordinates 1359747..1360193 (-) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF60_RS06470 (1354923) 1354923..1355819 + 897 WP_227786933.1 sugar kinase -
LJF60_RS06475 (1355853) 1355853..1356656 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LJF60_RS06480 (1356847) 1356847..1357446 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF60_RS06485 (1357440) 1357440..1358312 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF60_RS06490 (1358309) 1358309..1358746 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF60_RS06495 (1358791) 1358791..1359732 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF60_RS06500 (1359747) 1359747..1360193 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LJF60_RS06505 (1360190) 1360190..1360501 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin Toxin
LJF60_RS06510 (1360587) 1360587..1361516 - 930 WP_001127705.1 alpha/beta hydrolase -
LJF60_RS06515 (1361734) 1361734..1362045 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
LJF60_RS06520 (1362046) 1362046..1362336 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
LJF60_RS06525 (1362383) 1362383..1363312 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF60_RS06530 (1363309) 1363309..1363944 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF60_RS06535 (1363941) 1363941..1364843 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12324.26 Da        Isoelectric Point: 9.3143

>T221362 WP_000558168.1 NZ_CP085794:c1360501-1360190 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Download         Length: 312 bp

>T221362 NZ_CP117382:c4309158-4308667 [Salmonella enterica subsp. enterica serovar Uganda]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT221362 WP_001259009.1 NZ_CP085794:c1360193-1359747 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT221362 NZ_CP117382:c4309448-4309155 [Salmonella enterica subsp. enterica serovar Uganda]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1R2S541


Antitoxin

Source ID Structure

References