Detailed information of TA system TA221348

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2090907..2091132
• Replicon: chromosome
• Accession: NZ_CP085793
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF61_RS10135
• Protein ID: WP_000813254.1
• Coordinates: 2090977..2091132 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2090907..2090965 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF61_RS10095	2086008..2086229	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF61_RS10100	2086667..2087188	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF61_RS10105	2087296..2087451	-	156	WP_085981757.1	DUF1391 family protein	-
LJF61_RS10110	2087836..2088303	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF61_RS22975	2088485..2088532	+	48	Protein_1959	hypothetical protein	-
LJF61_RS10120	2088576..2088905	+	330	WP_001676916.1	DUF977 family protein	-
LJF61_RS10125	2089067..2089621	-	555	WP_001033796.1	hypothetical protein	-
LJF61_RS10130	2089618..2090550	-	933	WP_000556390.1	hypothetical protein	-
-	2090907..2090965	-	59	-	-	Antitoxin
LJF61_RS10135	2090977..2091132	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF61_RS10140	2091423..2091593	+	171	WP_000734094.1	hypothetical protein	-
LJF61_RS10145	2091656..2092255	+	600	WP_000940751.1	DUF1367 family protein	-
LJF61_RS10150	2092255..2092545	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF61_RS10155	2092542..2093078	+	537	WP_000640113.1	DUF1133 family protein	-
LJF61_RS10160	2095249..2095572	+	324	Protein_1968	tellurite/colicin resistance protein	-
LJF61_RS10165	2095566..2095754	+	189	WP_001688615.1	putative holin	-
LJF61_RS10170	2095744..2096025	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2086667..2096567	9900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221348 WP_000813254.1 NZ_CP085793:2090977-2091132 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221348 NZ_CP117380:c4651623-4651312 [Salmonella enterica subsp. enterica serovar Newport]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT221348 NZ_CP085793:c2090965-2090907 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin