Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 45850..46452 Replicon chromosome
Accession NZ_CP085793
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain Poochyena

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag LJF61_RS00225 Protein ID WP_001159635.1
Coordinates 45850..46161 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJF61_RS00230 Protein ID WP_000362050.1
Coordinates 46162..46452 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJF61_RS00190 (40963) 40963..41562 + 600 WP_000965695.1 glucose-1-phosphatase -
LJF61_RS00195 (41556) 41556..42428 + 873 WP_000921423.1 virulence factor BrkB family protein -
LJF61_RS00200 (42425) 42425..42862 + 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
LJF61_RS00205 (42907) 42907..43848 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LJF61_RS00210 (43863) 43863..44309 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
LJF61_RS00215 (44306) 44306..44617 - 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
LJF61_RS00220 (44703) 44703..45632 - 930 WP_001127705.1 alpha/beta hydrolase -
LJF61_RS00225 (45850) 45850..46161 + 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
LJF61_RS00230 (46162) 46162..46452 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
LJF61_RS00235 (46499) 46499..47428 - 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
LJF61_RS00240 (47425) 47425..48060 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LJF61_RS00245 (48057) 48057..48959 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T221331 WP_001159635.1 NZ_CP085793:45850-46161 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T221331 NZ_CP117378:2045495-2045598 [Salmonella enterica subsp. enterica serovar Newport]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT221331 WP_000362050.1 NZ_CP085793:46162-46452 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT221331 NZ_CP117378:c2045600-2045455 [Salmonella enterica subsp. enterica serovar Newport]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References