Detailed information of TA system TA221328

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3847807..3848032
• Replicon: chromosome
• Accession: NZ_CP085792
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain Mightyena

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: LJF62_RS18515
• Protein ID: WP_000813254.1
• Coordinates: 3847877..3848032 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3847807..3847865 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJF62_RS18475	3842908..3843129	-	222	WP_000560208.1	cell division protein FtsZ	-
LJF62_RS18480	3843567..3844088	+	522	WP_000004762.1	super-infection exclusion protein B	-
LJF62_RS18485	3844196..3844351	-	156	WP_085981757.1	DUF1391 family protein	-
LJF62_RS18490	3844736..3845203	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
LJF62_RS23000	3845385..3845432	+	48	Protein_3589	hypothetical protein	-
LJF62_RS18500	3845476..3845805	+	330	WP_001676916.1	DUF977 family protein	-
LJF62_RS18505	3845967..3846521	-	555	WP_001033796.1	hypothetical protein	-
LJF62_RS18510	3846518..3847450	-	933	WP_000556390.1	hypothetical protein	-
-	3847807..3847865	-	59	-	-	Antitoxin
LJF62_RS18515	3847877..3848032	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
LJF62_RS18520	3848323..3848493	+	171	WP_000734094.1	hypothetical protein	-
LJF62_RS18525	3848556..3849155	+	600	WP_000940751.1	DUF1367 family protein	-
LJF62_RS18530	3849155..3849445	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
LJF62_RS18535	3849442..3849978	+	537	WP_000640113.1	DUF1133 family protein	-
LJF62_RS18540	3852149..3852472	+	324	Protein_3598	tellurite/colicin resistance protein	-
LJF62_RS18545	3852466..3852654	+	189	WP_001688615.1	putative holin	-
LJF62_RS18550	3852644..3852925	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3841596..3853467	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T221328 WP_000813254.1 NZ_CP085792:3847877-3848032 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T221328 NZ_CP117378:825644-826057 [Salmonella enterica subsp. enterica serovar Newport]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT221328 NZ_CP085792:c3847865-3847807 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin