Detailed information of TA system TA221243

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 138240..138900
• Replicon: chromosome
• Accession: NZ_CP085767
• Organism: Enterobacter hormaechei strain 49589CZ

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LJU37_RS00740
• Protein ID: WP_047053529.1
• Coordinates: 138547..138900 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2J0Q4Z7
• Locus tag: LJU37_RS00735
• Protein ID: WP_017383313.1
• Coordinates: 138240..138542 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU37_RS00720 (LJU37_00720)	134410..135735	+	1326	WP_047053533.1	SidA/IucD/PvdA family monooxygenase	-
LJU37_RS00725 (LJU37_00725)	135762..137951	+	2190	WP_047053531.1	TonB-dependent siderophore receptor	-
LJU37_RS00735 (LJU37_00735)	138240..138542	-	303	WP_017383313.1	XRE family transcriptional regulator	Antitoxin
LJU37_RS00740 (LJU37_00740)	138547..138900	-	354	WP_047053529.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LJU37_RS00745 (LJU37_00745)	139091..140041	-	951	WP_003859532.1	HTH-type transcriptional regulator Cbl	-
LJU37_RS00750 (LJU37_00750)	140138..141055	-	918	WP_003859531.1	nitrogen assimilation transcriptional regulator NAC	-
LJU37_RS00760 (LJU37_00760)	141544..142467	-	924	WP_047053526.1	L,D-transpeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (18-89)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13522.40 Da
• Isoelectric Point: 10.1729

>T221243 WP_047053529.1 NZ_CP085767:c138900-138547 [Enterobacter hormaechei]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFNPNRTGI
VLCAGNKIGNERRFYDEMLLVADREYTRWLNTLKERN

Nucleotide

• Length: 354 bp

>T221243 NZ_CP117365:c991281-990754 [Salmonella enterica subsp. enterica serovar Newport]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11028.85 Da
• Isoelectric Point: 6.4727

>AT221243 WP_017383313.1 NZ_CP085767:c138542-138240 [Enterobacter hormaechei]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Nucleotide

• Length: 303 bp

>AT221243 NZ_CP117365:c991568-991278 [Salmonella enterica subsp. enterica serovar Newport]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2J0Q4Z7