Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1748143..1748800 Replicon chromosome
Accession NZ_CP085757
Organism Enterobacter hormaechei strain 54569CZ

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LJU41_RS08410 Protein ID WP_032609983.1
Coordinates 1748143..1748442 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJU41_RS08415 Protein ID WP_032609984.1
Coordinates 1748453..1748800 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU41_RS08400 (LJU41_08400) 1744520..1746712 + 2193 Protein_1648 type I secretion system permease/ATPase -
LJU41_RS08405 (LJU41_08405) 1746693..1747892 + 1200 WP_060580209.1 HlyD family efflux transporter periplasmic adaptor subunit -
LJU41_RS08410 (LJU41_08410) 1748143..1748442 + 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJU41_RS08415 (LJU41_08415) 1748453..1748800 + 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
LJU41_RS08420 (LJU41_08420) 1748876..1750057 - 1182 WP_060580210.1 PLP-dependent aminotransferase family protein -
LJU41_RS08425 (LJU41_08425) 1750078..1750965 - 888 WP_032660046.1 LysR family transcriptional regulator -
LJU41_RS08430 (LJU41_08430) 1751063..1751665 + 603 WP_032660049.1 short chain dehydrogenase -
LJU41_RS08435 (LJU41_08435) 1751662..1752393 - 732 WP_032660054.1 class I SAM-dependent methyltransferase -
LJU41_RS08440 (LJU41_08440) 1752468..1753466 - 999 WP_045346167.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T221234 WP_032609983.1 NZ_CP085757:1748143-1748442 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T221234 NZ_CP117362:c4653483-4653172 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT221234 WP_032609984.1 NZ_CP085757:1748453-1748800 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT221234 NZ_CP117362:c4653171-4652881 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References