Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3142774..3143449 Replicon chromosome
Accession NZ_CP085753
Organism Enterobacter hormaechei strain 57816CZ

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag LJU43_RS15235 Protein ID WP_015571638.1
Coordinates 3143150..3143449 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag LJU43_RS15230 Protein ID WP_015571639.1
Coordinates 3142774..3143139 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU43_RS15210 (3139230) 3139230..3139961 + 732 WP_181494005.1 class I SAM-dependent methyltransferase -
LJU43_RS15215 (3139958) 3139958..3140560 - 603 WP_033487546.1 short chain dehydrogenase -
LJU43_RS15220 (3140658) 3140658..3141545 + 888 WP_062934064.1 LysR family transcriptional regulator -
LJU43_RS15225 (3141566) 3141566..3142747 + 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
LJU43_RS15230 (3142774) 3142774..3143139 - 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
LJU43_RS15235 (3143150) 3143150..3143449 - 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJU43_RS15240 (3143700) 3143700..3144899 - 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
LJU43_RS15245 (3144880) 3144880..3147072 - 2193 WP_181494004.1 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T221211 WP_015571638.1 NZ_CP085753:c3143449-3143150 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T221211 NZ_CP117359:c4145830-4145543 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT221211 WP_015571639.1 NZ_CP085753:c3143139-3142774 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp

>AT221211 NZ_CP117359:c4145556-4145254 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGATAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References