Detailed information of TA system TA022118

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2134508..2134815
• Replicon: chromosome
• Accession: NC_009487
• Organism: Staphylococcus aureus subsp. aureus JH9

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAURJH9_RS15570
• Protein ID: WP_011447039.1
• Coordinates: 2134639..2134815 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2134508..2134647 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAURJH9_RS10845	2129847..2130107	+	261	WP_001791826.1	hypothetical protein	-
SAURJH9_RS10850	2130160..2130510	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAURJH9_RS10855	2131195..2131644	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAURJH9_RS15890	2131739..2132074	-	336	Protein_2062	SH3 domain-containing protein	-
SAURJH9_RS10865	2132724..2133215	-	492	WP_000919350.1	staphylokinase	-
SAURJH9_RS10870	2133406..2134161	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAURJH9_RS10875	2134173..2134427	-	255	WP_000611512.1	phage holin	-
SAURJH9_RS10880	2134479..2134586	+	108	WP_001791821.1	hypothetical protein	-
-	2134508..2134647	+	140	NuclAT_0	-	Antitoxin
-	2134508..2134647	+	140	NuclAT_0	-	Antitoxin
-	2134508..2134647	+	140	NuclAT_0	-	Antitoxin
-	2134508..2134647	+	140	NuclAT_0	-	Antitoxin
SAURJH9_RS15570	2134639..2134815	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAURJH9_RS10890	2134965..2135261	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAURJH9_RS10895	2135319..2135606	-	288	WP_001040261.1	hypothetical protein	-
SAURJH9_RS10900	2135653..2135805	-	153	WP_001153681.1	hypothetical protein	-
SAURJH9_RS10905	2135795..2139580	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2130160..2183678	53518

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T22118 WP_011447039.1 NC_009487:c2134815-2134639 [Staphylococcus aureus subsp. aureus JH9]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T22118 NC_009487:c2134815-2134639 [Staphylococcus aureus subsp. aureus JH9]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT22118 NC_009487:2134508-2134647 [Staphylococcus aureus subsp. aureus JH9]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin