221175

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3828991..3829648 Replicon chromosome
Accession NZ_CP085743
Organism Enterobacter hormaechei strain 60214CZ

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LJU47_RS18595 Protein ID WP_032609983.1
Coordinates 3829349..3829648 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJU47_RS18590 Protein ID WP_032609984.1
Coordinates 3828991..3829338 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJU47_RS18565 (LJU47_18565) 3824325..3825323 + 999 WP_045346167.1 transketolase family protein -
LJU47_RS18570 (LJU47_18570) 3825398..3826129 + 732 WP_032660054.1 class I SAM-dependent methyltransferase -
LJU47_RS18575 (LJU47_18575) 3826126..3826728 - 603 WP_032660049.1 short chain dehydrogenase -
LJU47_RS18580 (LJU47_18580) 3826826..3827713 + 888 WP_032660046.1 LysR family transcriptional regulator -
LJU47_RS18585 (LJU47_18585) 3827734..3828915 + 1182 WP_060580210.1 PLP-dependent aminotransferase family protein -
LJU47_RS18590 (LJU47_18590) 3828991..3829338 - 348 WP_032609984.1 HigA family addiction module antitoxin Antitoxin
LJU47_RS18595 (LJU47_18595) 3829349..3829648 - 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJU47_RS18600 (LJU47_18600) 3829899..3831098 - 1200 WP_060580209.1 HlyD family efflux transporter periplasmic adaptor subunit -
LJU47_RS18605 (LJU47_18605) 3831079..3833271 - 2193 Protein_3619 type I secretion system permease/ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T221175 WP_032609983.1 NZ_CP085743:c3829648-3829349 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T221175 NZ_CP117354:c4145311-4145024 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT221175 WP_032609984.1 NZ_CP085743:c3829338-3828991 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT221175 NZ_CP117354:c4145037-4144735 [Salmonella enterica subsp. enterica serovar Dublin]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGATAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References