Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 61369..62026 | Replicon | plasmid p59062CZ_IncC_KPC |
| Accession | NZ_CP085731 | ||
| Organism | Klebsiella pneumoniae strain 59062CZ | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | LJU45_RS26960 | Protein ID | WP_000270043.1 |
| Coordinates | 61369..61719 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJU45_RS26965 | Protein ID | WP_000124640.1 |
| Coordinates | 61724..62026 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJU45_RS26925 (LJU45_26925) | 57843..58340 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| LJU45_RS26930 (LJU45_26930) | 58343..58831 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| LJU45_RS26935 (LJU45_26935) | 58928..59263 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| LJU45_RS26940 (LJU45_26940) | 59278..59748 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| LJU45_RS26945 (LJU45_26945) | 59741..60112 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| LJU45_RS26950 (LJU45_26950) | 60123..60317 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| LJU45_RS26955 (LJU45_26955) | 60658..61206 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| LJU45_RS26960 (LJU45_26960) | 61369..61719 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LJU45_RS26965 (LJU45_26965) | 61724..62026 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| LJU45_RS26970 (LJU45_26970) | 62053..62346 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| LJU45_RS26975 (LJU45_26975) | 62434..62706 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| LJU45_RS26980 (LJU45_26980) | 62764..63291 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| LJU45_RS26985 (LJU45_26985) | 63522..64379 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| LJU45_RS26990 (LJU45_26990) | 64366..64596 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| LJU45_RS26995 (LJU45_26995) | 64596..65114 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| LJU45_RS27000 (LJU45_27000) | 65111..65557 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| LJU45_RS27005 (LJU45_27005) | 65557..65916 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| LJU45_RS27010 (LJU45_27010) | 65973..66401 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaKPC-2 / aph(3')-Ia / aph(2'')-Ib / aac(6')-Im | - | 1..170174 | 170174 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T221139 WP_000270043.1 NZ_CP085731:61369-61719 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T221139 NZ_CP117348:3456382-3456600 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT221139 WP_000124640.1 NZ_CP085731:61724-62026 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT221139 NZ_CP117348:3455980-3456354 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|