Detailed information of TA system TA022112

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1081624..1082203
• Replicon: chromosome
• Accession: NC_009487
• Organism: Staphylococcus aureus subsp. aureus JH9

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAURJH9_RS05475
• Protein ID: WP_001025401.1
• Coordinates: 1081624..1081869 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1081838..1082203 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAURJH9_RS05430	1077642..1078256	+	615	WP_000191459.1	hypothetical protein	-
SAURJH9_RS05435	1078253..1078399	-	147	WP_001013104.1	hypothetical protein	-
SAURJH9_RS05440	1078629..1079213	-	585	WP_000825948.1	hypothetical protein	-
SAURJH9_RS05445	1079231..1079692	-	462	WP_000525004.1	hypothetical protein	-
SAURJH9_RS05450	1079705..1080019	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
SAURJH9_RS05455	1080171..1080407	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
SAURJH9_RS05460	1080421..1081197	+	777	WP_001148544.1	Rha family transcriptional regulator	-
SAURJH9_RS05465	1081226..1081369	+	144	WP_000939498.1	hypothetical protein	-
SAURJH9_RS05470	1081359..1081568	-	210	WP_000642492.1	hypothetical protein	-
SAURJH9_RS05475	1081624..1081869	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAURJH9_RS05480	1081838..1082203	-	366	WP_001128433.1	hypothetical protein	Antitoxin
SAURJH9_RS05485	1082258..1082473	+	216	WP_001097552.1	hypothetical protein	-
SAURJH9_RS05490	1082498..1082761	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
SAURJH9_RS05495	1082774..1082935	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
SAURJH9_RS05500	1083014..1083337	+	324	WP_000175002.1	hypothetical protein	-
SAURJH9_RS05505	1083352..1083714	+	363	WP_000985976.1	hypothetical protein	-
SAURJH9_RS05510	1083711..1084877	+	1167	WP_000762547.1	DUF2800 domain-containing protein	-
SAURJH9_RS05515	1084903..1085460	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1076311..1121184	44873

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T22112 WP_001025401.1 NC_009487:1081624-1081869 [Staphylococcus aureus subsp. aureus JH9]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T22112 NC_009487:1081624-1081869 [Staphylococcus aureus subsp. aureus JH9]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT22112 NC_009487:c1082203-1081838 [Staphylococcus aureus subsp. aureus JH9]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin