Detailed information of TA system TA221114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 4041352..4042052
• Replicon: chromosome
• Accession: NZ_CP085704
• Organism: Pseudomonas sp. HN2-3

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: LJX93_RS18310
• Protein ID: WP_227696268.1
• Coordinates: 4041756..4042052 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: A0A6L6TG18
• Locus tag: LJX93_RS18305
• Protein ID: WP_033699296.1
• Coordinates: 4041352..4041753 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJX93_RS18285 (LJX93_18285)	4036472..4037293	-	822	WP_033699287.1	transporter substrate-binding domain-containing protein	-
LJX93_RS18290 (LJX93_18290)	4037382..4038311	-	930	WP_033699289.1	FAD-binding protein	-
LJX93_RS18295 (LJX93_18295)	4038312..4039061	-	750	WP_033699291.1	electron transfer flavoprotein subunit beta/FixA family protein	-
LJX93_RS18300 (LJX93_18300)	4039618..4041282	+	1665	WP_033699293.1	electron transfer flavoprotein-ubiquinone oxidoreductase	-
LJX93_RS18305 (LJX93_18305)	4041352..4041753	-	402	WP_033699296.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LJX93_RS18310 (LJX93_18310)	4041756..4042052	-	297	WP_227696268.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LJX93_RS18315 (LJX93_18315)	4042147..4043472	-	1326	WP_047581286.1	MFS transporter	-
LJX93_RS18320 (LJX93_18320)	4043542..4044015	-	474	WP_033699301.1	response regulator	-
LJX93_RS18325 (LJX93_18325)	4044184..4044660	-	477	WP_033699303.1	sigma-70 family RNA polymerase sigma factor	-
LJX93_RS18330 (LJX93_18330)	4044892..4046064	+	1173	WP_227696269.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11185.10 Da
• Isoelectric Point: 10.0635

>T221114 WP_227696268.1 NZ_CP085704:c4042052-4041756 [Pseudomonas sp. HN2-3]
MEKRTPHCPLERIKALTAARRVSPTGTALRDAKALGMDFPGMLEVITSLKRTDFYKSMTSHIDHRVWQDVYRPFTAVGYV
YLKVSVVNDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T221114 NZ_CP117346:200056-200541 [Salmonella enterica subsp. enterica serovar Dublin]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14658.71 Da
• Isoelectric Point: 5.2050

>AT221114 WP_033699296.1 NZ_CP085704:c4041753-4041352 [Pseudomonas sp. HN2-3]
MRCPICGGAELAPDTQGMPYRYKGETTLIPDVSGDYCSACGECVLSHDQAMRVSDLMTAFERQVNATVVDPSFIASIRRK
FDLDQRQAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Nucleotide

• Length: 402 bp

>AT221114 NZ_CP117346:199781-200068 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6L6TG18