Detailed information of TA system TA221110

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 42652..42916
• Replicon: plasmid pS29-IncI1
• Accession: NZ_CP085700
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S29

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: LJN59_RS24795
• Protein ID: WP_001387489.1
• Coordinates: 42764..42916 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	42652..42712 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJN59_RS24780 (38754)	38754..39824	-	1071	WP_012783932.1	IncI1-type conjugal transfer protein TrbB	-
LJN59_RS24785 (39843)	39843..41051	-	1209	WP_001703845.1	IncI1-type conjugal transfer protein TrbA	-
- (41231)	41231..41288	-	58	NuclAT_1	-	-
- (41231)	41231..41288	-	58	NuclAT_1	-	-
- (41231)	41231..41288	-	58	NuclAT_1	-	-
- (41231)	41231..41288	-	58	NuclAT_1	-	-
LJN59_RS24790 (41358)	41358..42443	-	1086	WP_000080543.1	protein finQ	-
- (42652)	42652..42712	-	61	NuclAT_0	-	Antitoxin
- (42652)	42652..42712	-	61	NuclAT_0	-	Antitoxin
- (42652)	42652..42712	-	61	NuclAT_0	-	Antitoxin
- (42652)	42652..42712	-	61	NuclAT_0	-	Antitoxin
LJN59_RS24795 (42764)	42764..42916	+	153	WP_001387489.1	Hok/Gef family protein	Toxin
LJN59_RS24800 (42988)	42988..43239	-	252	WP_001291964.1	hypothetical protein	-
LJN59_RS24805 (43539)	43539..43835	+	297	WP_011264046.1	DinQ-like type I toxin DqlB	-
LJN59_RS24810 (43900)	43900..44076	-	177	WP_001054900.1	hypothetical protein	-
LJN59_RS24815 (44468)	44468..44677	+	210	WP_000062603.1	HEAT repeat domain-containing protein	-
LJN59_RS24820 (44749)	44749..45411	-	663	WP_012783935.1	plasmid IncI1-type surface exclusion protein ExcA	-
LJN59_RS24825 (45482)	45482..47650	-	2169	WP_015508354.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-55	-	1..88502	88502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T221110 WP_001387489.1 NZ_CP085700:42764-42916 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T221110 NZ_CP117344:c14266-13916 [Salmonella enterica subsp. enterica serovar Dublin]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT221110 NZ_CP085700:c42712-42652 [Salmonella enterica subsp. enterica serovar Typhimurium]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin