Detailed information of TA system TA221108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4807042..4807644
• Replicon: chromosome
• Accession: NZ_CP085699
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S29

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: LJN59_RS23590
• Protein ID: WP_001159630.1
• Coordinates: 4807333..4807644 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LJN59_RS23585
• Protein ID: WP_000362050.1
• Coordinates: 4807042..4807332 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJN59_RS23570 (4804535)	4804535..4805437	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
LJN59_RS23575 (4805434)	4805434..4806069	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
LJN59_RS23580 (4806066)	4806066..4806995	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
LJN59_RS23585 (4807042)	4807042..4807332	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
LJN59_RS23590 (4807333)	4807333..4807644	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
LJN59_RS23595 (4807862)	4807862..4808791	+	930	WP_001127703.1	alpha/beta hydrolase	-
LJN59_RS23600 (4808877)	4808877..4809188	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
LJN59_RS23605 (4809185)	4809185..4809631	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
LJN59_RS23610 (4809646)	4809646..4810587	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
LJN59_RS23615 (4810632)	4810632..4811069	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
LJN59_RS23620 (4811066)	4811066..4811938	-	873	WP_000921427.1	virulence factor BrkB family protein	-
LJN59_RS23625 (4811932)	4811932..4812531	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T221108 WP_001159630.1 NZ_CP085699:c4807644-4807333 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T221108 NZ_CP117343:c4653201-4652890 [Salmonella enterica subsp. enterica serovar Dublin]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT221108 WP_000362050.1 NZ_CP085699:c4807332-4807042 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT221108 NZ_CP117343:c4652889-4652599 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64