221066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 358945..359483 Replicon chromosome
Accession NZ_CP085696
Organism Salmonella enterica subsp. enterica serovar Saintpaul strain S25

Toxin (Protein)


Gene name yafQ Uniprot ID A0A7U1Q7V6
Locus tag LJN58_RS01620 Protein ID WP_001521736.1
Coordinates 359208..359483 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A5V2G724
Locus tag LJN58_RS01615 Protein ID WP_000729830.1
Coordinates 358945..359205 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN58_RS01600 (354700) 354700..356253 + 1554 WP_000013017.1 TROVE domain-containing protein -
LJN58_RS01605 (356599) 356599..357813 + 1215 WP_001105524.1 RNA-splicing ligase RtcB -
LJN58_RS01610 (357817) 357817..358836 + 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
LJN58_RS01615 (358945) 358945..359205 + 261 WP_000729830.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LJN58_RS01620 (359208) 359208..359483 + 276 WP_001521736.1 type II toxin-antitoxin system YafQ family toxin Toxin
LJN58_RS01625 (359571) 359571..362276 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10618.25 Da        Isoelectric Point: 9.7714

>T221066 WP_001521736.1 NZ_CP085696:359208-359483 [Salmonella enterica subsp. enterica serovar Saintpaul]
MGQRKIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIGPDWILIDKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T221066 NZ_CP117338:2044895-2044998 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9473.87 Da        Isoelectric Point: 4.6028

>AT221066 WP_000729830.1 NZ_CP085696:358945-359205 [Salmonella enterica subsp. enterica serovar Saintpaul]
MAANVLVRARIDETLKNQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT221066 NZ_CP117338:c2045000-2044855 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1Q7V6

Antitoxin

Source ID Structure
AlphaFold DB A0A5V2G724

References