Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3864578..3865377 Replicon chromosome
Accession NZ_CP085638
Organism Escherichia coli strain fEC.1

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag LJX82_RS18615 Protein ID WP_000347267.1
Coordinates 3864578..3865042 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LJX82_RS18620 Protein ID WP_001307405.1
Coordinates 3865042..3865377 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJX82_RS18585 (3859579) 3859579..3860013 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LJX82_RS18590 (3860031) 3860031..3860909 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
LJX82_RS18595 (3860899) 3860899..3861678 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LJX82_RS18600 (3861689) 3861689..3862162 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LJX82_RS18605 (3862185) 3862185..3863465 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
LJX82_RS18610 (3863714) 3863714..3864523 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LJX82_RS18615 (3864578) 3864578..3865042 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LJX82_RS18620 (3865042) 3865042..3865377 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LJX82_RS18625 (3865526) 3865526..3867097 - 1572 WP_001273741.1 galactarate dehydratase -
LJX82_RS18630 (3867472) 3867472..3868806 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
LJX82_RS18635 (3868822) 3868822..3869592 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T221044 WP_000347267.1 NZ_CP085638:c3865042-3864578 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T221044 NZ_CP117336:824533-824946 [Salmonella enterica subsp. enterica serovar Dublin]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGTCAACACTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT221044 WP_001307405.1 NZ_CP085638:c3865377-3865042 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT221044 NZ_CP117336:824286-824552 [Salmonella enterica subsp. enterica serovar Dublin]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References