Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2806723..2807225 | Replicon | chromosome |
| Accession | NZ_CP085638 | ||
| Organism | Escherichia coli strain fEC.1 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | LJX82_RS13685 | Protein ID | WP_000767829.1 |
| Coordinates | 2806723..2806977 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | LJX82_RS13690 | Protein ID | WP_001259255.1 |
| Coordinates | 2806974..2807225 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJX82_RS13655 (2801738) | 2801738..2801965 | - | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| LJX82_RS13660 (2801979) | 2801979..2803037 | - | 1059 | WP_023568741.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| LJX82_RS13665 (2803216) | 2803216..2804574 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| LJX82_RS13670 (2804564) | 2804564..2804626 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| LJX82_RS13675 (2804841) | 2804841..2805770 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| LJX82_RS13680 (2805816) | 2805816..2806640 | - | 825 | WP_000754749.1 | SDR family oxidoreductase | - |
| LJX82_RS13685 (2806723) | 2806723..2806977 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| LJX82_RS13690 (2806974) | 2806974..2807225 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| LJX82_RS13695 (2807508) | 2807508..2807558 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| LJX82_RS13700 (2807704) | 2807704..2808603 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| LJX82_RS13705 (2808609) | 2808609..2809913 | + | 1305 | WP_001499066.1 | histidinol dehydrogenase | - |
| LJX82_RS13710 (2809910) | 2809910..2810980 | + | 1071 | WP_000108950.1 | histidinol-phosphate transaminase | - |
| LJX82_RS13715 (2810980) | 2810980..2812047 | + | 1068 | WP_000080093.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T221040 WP_000767829.1 NZ_CP085638:c2806977-2806723 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T221040 NZ_CP117334:46086-46376 [Salmonella enterica subsp. enterica serovar Muenster]
CTGAAGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTT
GAAAAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGA
TTAAGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGG
AAAAGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
CTGAAGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTT
GAAAAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGA
TTAAGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGG
AAAAGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT221040 WP_001259255.1 NZ_CP085638:c2807225-2806974 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT221040 NZ_CP117334:45847-46089 [Salmonella enterica subsp. enterica serovar Muenster]
TTGCAACAGTGCCTTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAAC
TCCTTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTG
ATGAAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTC
TGA
TTGCAACAGTGCCTTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAAC
TCCTTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTG
ATGAAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTC
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|