Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 833268..833809 Replicon chromosome
Accession NZ_CP085638
Organism Escherichia coli strain fEC.1

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag LJX82_RS03840 Protein ID WP_000615982.1
Coordinates 833268..833546 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag LJX82_RS03845 Protein ID WP_000729704.1
Coordinates 833549..833809 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJX82_RS03825 (830850) 830850..831428 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
LJX82_RS03830 (831634) 831634..832401 + 768 WP_000333380.1 class II glutamine amidotransferase -
LJX82_RS03835 (832372) 832372..833112 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
LJX82_RS03840 (833268) 833268..833546 - 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
LJX82_RS03845 (833549) 833549..833809 - 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
LJX82_RS03850 (833995) 833995..834768 + 774 WP_000543899.1 C40 family peptidase -
LJX82_RS03855 (834825) 834825..835181 - 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
LJX82_RS03860 (835174) 835174..835452 - 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
LJX82_RS03865 (835557) 835557..837269 - 1713 Protein_746 flagellar biosynthesis protein FlhA -
LJX82_RS03870 (837241) 837241..838026 + 786 WP_000207575.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T221025 WP_000615982.1 NZ_CP085638:c833546-833268 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T221025 NZ_CP117330:47505-47792 [Salmonella enterica subsp. enterica serovar Muenster]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT221025 WP_000729704.1 NZ_CP085638:c833809-833549 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT221025 NZ_CP117330:47266-47505 [Salmonella enterica subsp. enterica serovar Muenster]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAAGCCTAAGCCAGTACGTGTGACGCTGGATGAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References