Detailed information of TA system TA221019

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3958801..3959059
• Replicon: chromosome
• Accession: NZ_CP085637
• Organism: Escherichia coli strain fECg99.1

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: LJU33_RS19055
• Protein ID: WP_000809168.1
• Coordinates: 3958907..3959059 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3958801..3958858 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJU33_RS19035	3953828..3955180	+	1353	Protein_3719	fimbria/pilus outer membrane usher protein	-
LJU33_RS19040	3955193..3956151	+	959	Protein_3720	fimbrial family protein	-
LJU33_RS19045	3956190..3957089	-	900	WP_001300855.1	transcriptional activator NhaR	-
LJU33_RS19050	3957155..3958321	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3958801..3958858	-	58	-	-	Antitoxin
LJU33_RS19055	3958907..3959059	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
LJU33_RS19060	3959163..3960293	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
LJU33_RS19065	3960382..3962298	-	1917	WP_000516135.1	molecular chaperone DnaK	-
LJU33_RS19070	3962675..3963079	+	405	WP_000843559.1	DUF2541 family protein	-
LJU33_RS19075	3963105..3963818	+	714	WP_001102379.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T221019 WP_000809168.1 NZ_CP085637:3958907-3959059 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T221019 NZ_CP117329:c4032321-4031980 [Salmonella enterica subsp. enterica serovar Muenster]
ATGCAAACCCAATACAACCACCCACACCGGGCGACCCCGTCACAGCCGTCGCCTGTCGAAATCTGGCAAAAACTGCTGAC
CCATTTACTGGCTAAACATTATGGCCTCGAACTCAGTGACACGCCGTTTAGCGTAGAGAAGGTGATTCAGGAACACATTG
ACGCCGGTATCACGCTGGCTAATGCCGTGAACTTTATTGTGGAGAAATACGAACTGGTTCGTATCGATCGCAAGGGATTT
AGCTGGCAGGAACAATCACCCTATCTCCGGGCTGTAGACATTCTGCGGGCGCGACAGGCTACGGGTCTGTTGCGACGTCA
ACGCTATCTCGCGGCACACTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT221019 NZ_CP085637:c3958858-3958801 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin