Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4461942..4462382 Replicon chromosome
Accession NC_009483
Organism Geobacter uraniireducens Rf4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GURA_RS23750 Protein ID WP_083764960.1
Coordinates 4462239..4462382 (-) Length 48 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag GURA_RS19440 Protein ID WP_011940618.1
Coordinates 4461942..4462226 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GURA_RS23745 4457347..4459482 - 2136 WP_011940613.1 ATP-binding cassette domain-containing protein -
GURA_RS19420 4459680..4460009 - 330 WP_011940614.1 type II toxin-antitoxin system PemK/MazF family toxin -
GURA_RS19425 4459996..4460244 - 249 WP_041245564.1 DUF2281 domain-containing protein -
GURA_RS19430 4460405..4460761 - 357 WP_041246163.1 four helix bundle protein -
GURA_RS19435 4460895..4461707 - 813 WP_011940617.1 ABC transporter permease -
GURA_RS19440 4461942..4462226 - 285 WP_011940618.1 HigA family addiction module antidote protein Antitoxin
GURA_RS23750 4462239..4462382 - 144 WP_083764960.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GURA_RS19450 4462631..4464192 + 1562 WP_085949360.1 IS3-like element ISGur6 family transposase -
GURA_RS19455 4464541..4465227 - 687 WP_011940619.1 hypothetical protein -
GURA_RS19465 4466148..4466612 + 465 WP_041245373.1 helix-turn-helix domain-containing protein -
GURA_RS19470 4466578..4467318 + 741 WP_083764835.1 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-47)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(2-81)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5411.05 Da        Isoelectric Point: 4.4369

>T22101 WP_083764960.1 NC_009483:c4462382-4462239 [Geobacter uraniireducens Rf4]
MNLPGLRLHGLSGDFDGFWSVDVSGNWRVVFRIEGKDVLDVDYLDYH

Download         Length: 144 bp

>T22101 NC_009483:c4462382-4462239 [Geobacter uraniireducens Rf4]
ATGAATCTTCCCGGCCTCAGGTTGCATGGCCTGAGCGGAGATTTTGACGGGTTTTGGTCTGTGGATGTCAGTGGCAACTG
GCGAGTCGTTTTCAGGATTGAAGGGAAGGACGTTTTGGATGTCGACTACCTGGATTACCATTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10347.08 Da        Isoelectric Point: 8.0702

>AT22101 WP_011940618.1 NC_009483:c4462226-4461942 [Geobacter uraniireducens Rf4]
MMHNPPHPGEVIRELCIKPLGISVTQAAKALGVSRKALSELLNGHAGISPEMAIRLSIAFDTTPESWLTQQVQYDLSLAE
QKRKDLKVERLMAA

Download         Length: 285 bp

>AT22101 NC_009483:c4462226-4461942 [Geobacter uraniireducens Rf4]
ATGATGCACAACCCACCCCATCCCGGAGAGGTGATCCGGGAACTTTGCATCAAGCCCCTCGGCATTTCCGTCACCCAGGC
GGCAAAGGCCCTTGGAGTTTCCCGCAAGGCCCTTTCCGAGCTATTGAACGGTCATGCCGGGATAAGCCCGGAGATGGCGA
TTCGCTTGTCCATCGCATTCGATACAACACCTGAAAGCTGGTTGACCCAGCAGGTTCAGTACGACCTTTCGCTGGCCGAG
CAGAAACGGAAAGACCTGAAGGTCGAAAGGCTGATGGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References