Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2057575..2058137 Replicon chromosome
Accession NZ_CP085627
Organism Erwinia rhapontici strain BY21311

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LJN55_RS09730 Protein ID WP_133843348.1
Coordinates 2057575..2057853 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LJN55_RS09735 Protein ID WP_159337278.1
Coordinates 2057853..2058137 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LJN55_RS09695 (LJN55_09695) 2052691..2053002 + 312 WP_227536143.1 hypothetical protein -
LJN55_RS09700 (LJN55_09700) 2053071..2053280 - 210 WP_227536144.1 hypothetical protein -
LJN55_RS09710 (LJN55_09710) 2053890..2055428 + 1539 WP_227536146.1 cryptochrome/photolyase family protein -
LJN55_RS09715 (LJN55_09715) 2055425..2055565 + 141 WP_227536147.1 DUF2256 domain-containing protein -
LJN55_RS09720 (LJN55_09720) 2055709..2056128 + 420 WP_133843318.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
LJN55_RS09725 (LJN55_09725) 2056131..2057393 + 1263 WP_227536148.1 translesion error-prone DNA polymerase V subunit UmuC -
LJN55_RS09730 (LJN55_09730) 2057575..2057853 + 279 WP_133843348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LJN55_RS09735 (LJN55_09735) 2057853..2058137 + 285 WP_159337278.1 HigA family addiction module antitoxin Antitoxin
LJN55_RS09740 (LJN55_09740) 2058172..2058318 - 147 WP_159337277.1 hypothetical protein -
LJN55_RS09745 (LJN55_09745) 2058592..2058972 + 381 WP_133843352.1 putative holin -
LJN55_RS09750 (LJN55_09750) 2058959..2059246 + 288 WP_227536149.1 phage holin family protein -
LJN55_RS09755 (LJN55_09755) 2059426..2061177 + 1752 WP_227536150.1 glycosyl hydrolase family 28-related protein -
LJN55_RS09760 (LJN55_09760) 2061478..2061678 + 201 WP_133843358.1 hypothetical protein -
LJN55_RS09765 (LJN55_09765) 2061690..2061938 - 249 WP_133843360.1 hypothetical protein -
LJN55_RS09770 (LJN55_09770) 2062205..2062450 - 246 WP_133843362.1 DinI-like family protein -
LJN55_RS09775 (LJN55_09775) 2062605..2062829 + 225 WP_227536151.1 YgdI/YgdR family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2050349..2065334 14985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10553.12 Da        Isoelectric Point: 7.3176

>T220974 WP_133843348.1 NZ_CP085627:2057575-2057853 [Erwinia rhapontici]
MIKSFKHKGLKKFFLKDDSSGIEQKLVGRIRNRLTVIDAAEKIGAIDMPGYDLHPLKGDRQEMWSVSVSGNWRITFTFID
GDAEILNLEDYH

Download         Length: 279 bp

>T220974 NZ_CP117322:c981730-981203 [Salmonella enterica subsp. enterica serovar Derby]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATACACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10374.99 Da        Isoelectric Point: 9.8926

>AT220974 WP_159337278.1 NZ_CP085627:2057853-2058137 [Erwinia rhapontici]
MKMANPAHPGEIIAEALDDMRVSVRQFARAMEIAPSTASRLLSGYTAVTPEMALRLAIVVGSTAETWMKIQTNYSLHQAR
QTLDTRHLHRLSAA

Download         Length: 285 bp

>AT220974 NZ_CP117322:c982017-981727 [Salmonella enterica subsp. enterica serovar Derby]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References